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Amylin receptor activation in the area postrema and brainstem promotes feelings of fullness and reduces meal size

Increased fatigue during activities that didn't tire you before Slower recovery from exercise Visible changes in areas like the legs, glutes, or face that look more deflated than lean Loss of muscle definition even as the scale drops These signals aren't diagnostic, but they're meaningful

The beneficial effect of tirzepatide on hsCRP, a biomarker of systemic inflammation, YKL-40, a proinflammatory cytokine, and ICAM-1, a biomarker of endothelial dysfunction, was already detectable at 4 weeks, consistent with the salutary effects of GIP and GLP-1 on inflammation and atherosclerosis in experimental models [84,85,86]

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