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Key points: Your starting weight affects both the total and the percentage of weight you lose Taking the medication consistently is more important than focusing on reaching the highest dose Staying on the lowest effective dose and losing weight at around 1 lb a week helps protect muscle Eating enough protein through a diet based on whole foods, and doing some resistance training will protect against muscle and bone loss during weight loss Side effects at different doses Side effects tend to become more common at higher doses

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Abstract Diabetes mellitus and osteoporosis are closely related and have complex influencing factors