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Recent advancements in sustained-release formulations, like PLGA nanoparticles for delivering exendin-4, show promise in preclinical models but still require validation in human studies (Wang et al., 2023)
J Neurochem 70:26132619 Kunnecke B, Cerdan S, Seelig J (1993) Cerebral metabolism of [1,2-13C2]glucose and [U-13C4]3-hydroxybutyrate in rat brain as detected by 13 C NMR spectroscopy
The pathophysiology involves multiple mechanisms, including metabolic disturbances from chronic hyperglycaemia, oxidative stress, inflammation, and microvascular insufficiency that compromises nerve blood supply
An unopened, refrigerated compounded semaglutide vial typically has a beyond-use date of 90 to 180 days from the compounding date
