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Supplementing with topical GHK-Cu can help restore some of these lost protective functions by delivering copper ions directly to the scalp, where they serve as essential cofactors for enzymes involved in tissue repair and hair follicle maintenance

In this context, GLP-1 microbiome support is best understood as a systems-based approach that connects SCFA production, gut barrier stability, microbial diversity, and long-term metabolic resilience

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DOI: Published online: May 1, 2025 1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea 2 Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea Corresponding author: Jae Hyun Bae Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea E-mail: [email protected] Copyright 2025 Korean Diabetes Association This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited