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Most of the mutant animals die shortly after birth ( Igf-1 null mice that reach adulthood have relative body weights dropping to 32% compared to that of normal animals ( igf-1 null mice and the reported human case of igf-1 mutation, a number of non-skeletal phenotypic differences do exist
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Moreover, it has been demonstrated that among obese adults with metabolic syndrome, those at high risk for OSA experience less body weight loss in response to dietary counselling, compared to adults with low risk for OSA [29]
