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and gluconeogenesis is suppressed 38 in part due to depletion of pyruvate and lactate 39

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One study reported that the depletion of APP using siRNA or antibodies in vivo reduced long-term potentiation (LTP) in mouse brains, crucial to memory formation, that could be rescued by the addition of exogenous human A 142 (Puzzo et al., 2011)

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