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Since it participates in the synthesis of GSH, this enzyme plays a key role in the cellular redox homoeostasis (12)
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Gln-derived aKG is essential for KDM4C-mediated epigenetic regulation of cFLIP The above data indicate that cFLIP downregulation caused by Gln deprivation leads to TRAIL-induced apoptosis in PDAC cells and that aKG supplementation reverses the reduction in the cFLIP level induced by Gln deprivation and rescues PDAC cells from TRAIL-induced apoptosis
In the vast majority of cases, yes
Li W, Luo S, Lin W, Hu X, Zhou D, Xu W, et al
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