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Diagnosis is made by exclusion of alcohol abuse and other causes of liver disease (HBV-related hepatitis, HCV-related hepatitis, autoimmune liver diseases, polycystic ovary syndrome, drug-induced liver disease and congenital causes such as hereditary hemochromatosis, Wilsons disease, alpha-1 antitrypsin deficit)

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The allele with five Ala repeats is significantly associated with breast cancer risk

It is likely that SRLs in development for other conditions such as acromegaly [e.g