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Similarly, T-helper cell 17 skewing condition (TGF-, IL-23, IL-6, IL-1, and IL-21) also results in increased DPP-4 expression [34]
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Despite the eventual recognition that most forms of ALS have different pathologic hallmarks, the discovery of SOD1 led to the development of SOD1 transgenic mouse models, which continue to be the foundation for studying potential ALS therapies
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