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According to product information, methotrexate-induced nausea affects a significant proportion of patients, whilst GLP-1 agonists frequently cause gastrointestinal side effects, particularly during dose escalation

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GLP-1 also promotes neurogenesis by stimulating neurotrophic factors as GDNF, VEGF, and BDNF and reduces inflammation by decreasing TNF-a, IL-6, IL-10, and microglial activation (Erbil et al., In addition to its role in neuroprotection, current evidence showed that GLP-1 affects reward pathways