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Tyrosine-7 is an essential residue for the catalytic activity of human class PI glutathione S-transferase: chemical modification and site-directed mutagenesis studies
Under conditions with overwhelming nitrosative stress, the signalling kinase pathway phosphoinositide-3-Kinases/v-Akt murine thymoma viral oncogene (PI3K/AKT) is involved in the activation of Nrf2 and the Nrf2-dependent genes [66]
Animal studies are limited and human data are lacking, making it difficult to assess potential risks to the fetus or nursing infant
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