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Hyperhomocysteinemia decreases GSH peroxidase activity leading to the prevalence of GSSG on GSH with the GSH/GSSG impaired ratio causing some common cardiovascular and neurodegenerative disorders (159)
KD lowers insulin, causing a decrease in IGF-1, which consequently leads to an increase in IGFBP-3 (191)
Early recognition and treatment are vital, as prolonged deficiency can cause potentially irreversible nerve damage
A randomized, double-blind, placebo-controlled clinical trial conducted in 30 healthy Filipino women aged 3050 years has provided some evidence favouring the efficacy of topical 2% GSSG lotion in temporary skin lightening
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