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Rather than relying on massive surplus to ensure adequate nutrients for muscle building, the improved insulin sensitivity and nutrient partitioning from Retatrutide may allow muscle growth from smaller surpluses that would normally be insufficient

Sebastian Badulescu et al., Glucagon-like peptide 1 agonist and effects on reward behaviour: A systematic review, Physiology & Behavior (June 2024), 111, [147]

Renal clearance sits alongside cardiac history and gastrointestinal tolerance as the safety factors it says drive the decision