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Mood disorders are commonly seen in children and adolescents, with an estimated rate of 15% suffering from any mood disorder, and 12% have a mood disorder with severe impairment, according to a study by Merikangas KR et al

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These elements establish a feedback loop that delays tissue repair, making it essential to precisely regulate the localized microenvironment to address multiple pathogenic mechanisms simultaneously

Cheedella NK, Suzuki A, Xiao L, Hofstetter WL, Maru DM, Taketa T, Sudo K, Blum MA, Lin SH, Welch J, Lee JH, Bhutani MS, Rice DC, Vaporciyan AA, Swisher SG , Ajani JA