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10.1136/jnnp-2023-331131 71 MalcolmR.LiaoJ.MichelM.CochranK.PyeW.YeagerD.et al (2002)
Evidence shows that the strongest genetic risk factor for late-onset AD is the E4 allele of the cholesterol transporter APOE (APOE4), besides, APOE4 could promote amyloid aggregation and impair clearance from the brain directly binding to A (63)
Glutathione is a tightly regulated intracellular constituent, and is limited in its production by negative feedback inhibition of its own synthesis through the enzyme gamma-glutamylcysteine synthetase, thus greatly minimizing any possibility of overdosage
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