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In a study of 80 obese people with type 2 diabetes receiving semaglutide and dulaglutide, a 20% reduction in the thickness of EAT was observed (62) One meta-analysis demonstrated the cardioprotective effects of GLP-1 RAs, showing reductions in blood pressure and lipid profile, with a significant increase in HDL levels (63)
The 1998 report found ipamorelin released GH without elevating ACTH or cortisol beyond what GHRH stimulation produced, and later work describes no significant elevation of prolactin, FSH, LH or TSH even at doses reported as more than 200-fold above the GH-releasing ED50
IGF-1 Signaling in Tissue and Cellular Models
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