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That single human study was a 12-patient retrospective case series of intra-articular BPC-157 injection for chronic knee pain, in which 7 of 12 patients (58%) reported self-described relief lasting more than 6 months
Ketamine is administered intravenously, but a derivative intranasal drug (esketamine [Ketanest]) has been approved for treating intractable depression
Nature, 432(7016), 466472
Long-term follow-up studies are needed to assess durability of therapeutic effects and to identify any delayed adverse effects or complications that might not be apparent in shorter-term investigations
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