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In preclinical models, GIP has been shown to decrease food intake and increase energy expenditure therefore resulting in weight reductions, and when combined with GLP-1 receptor agonism, may result in greater effects on markers of metabolic dysregulation such as body weight, glucose and lipids. Incretin hormones are released whenever food is consumed

The correct guidance is: if you're thinking about taking a dose early, ask yourself whether this is a one-time schedule adjustment (safe) or the third time this month you've wanted to dose early (pattern problem requiring a permanent schedule change)

Noria SF, Shelby RD, Atkins KD, et al

HFD, high-fat diet