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Higher GLP-1 levels inversely correlate with binge-like eating in animals 210,211 , and binging behavior is associated with lower GLP-1R in the nucleus of the solitary tract 212
Risk of Gastrointestinal Adverse Events Associated With Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss
Furthermore, in a 12-week trial, semaglutide was shown to reduce body weight predominantly through appetite suppression, but this effect was also accompanied by a marked reduction in preference for high-fat foods (Blundell et al., 2017)
As with most medical breakthroughs, the development and implementation of GLP-1 RA drugs is not straightforward
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