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While the copper tripeptide contains histidine (which can be oxidized to 2-oxo-histidine), this residue is already coordinated to the copper ion, and the complexs high stability constant means the copper is not freely available for catalysis
This means your tissues don't get enough oxygen-rich blood, leading to symptoms like fatigue and paleness
One example is PepHAR, a generative model that identifies key residue hot spots that influence how peptides bind to their targets (Li et al., 2025)
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