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Consequently, Schulzs groundbreaking observations of a biphasic, stimulatory-inhibitory response were largely dismissed by his contemporaries as experimental anomalies, delaying the formal recognition of hormesis for decades

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The results of the SURE-PD trial revealed that treatment with inosine for up to 24 months was clinically safe and well-tolerated at doses that elevated serum UA concentrations from a mean of 4.5 mg/dL to 6.17.0 and 7.18.0 mg/dL [104]