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According to the NIH Office of Dietary Supplements, B12 supplementation does not improve athletic performance in athletes with sufficient B12 status. This statement, backed by decades of research, contradicts much of what youll hear in medical spa waiting rooms

Although pharmacological inhibitors like 3-MA have been used to infer involvement of autophagy (Hu et al., 2024), systematic evaluation of drug metabolism, long-term toxicity, and in vivo efficacy remains limited

For some, particularly those with permanent malabsorption issues, injections are a regular, lifelong requirement, typically lasting between two to three months per dose

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