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For example, denosumab, a RANKL mono-antibody, can hardly control the inflammation of RA in clinical practices 18
Prior plant studies support the plausibility of this approach where stress combined with epigenetic perturbation has been shown to increase extrachromosomal retrotransposon DNA and mobilization outputs, and long-read eccDNA profiling under epigenetic stress has revealed dramatic, family-specific bursts of eccDNA production (Thieme et al., 2017
Swisher SG , Roth JA, Neumanitis J, Lawrence DD, Kemp BL, Carrasco CH, Connors C, El-Nagger AK, Fossela FV, Glisson BS, Hong WK, Khuri FR, Kurie JM, Lee JJ, Lee JS, Merritt JA, Nesbitt JC, Nguyen D, Pisters KMW, Jr PJ, Schrump DS, Shin DM, Perez-Soler R, Walsh GL
Metzler B, Gfeller P, Guinet E
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