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While semaglutide does not directly increase estrogen, the weight loss it produces can reduce excess aromatase activity and normalize estrogen ratios, particularly in women who are carrying excess visceral fat
Specifically, serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured to evaluate liver function, while blood urea nitrogen (BUN) and creatinine were measured to assess kidney function
327 Importantly, similar to those treated with febuxostat, patients on benzbromarone exhibited a significantly reduced risk of advancing to end-stage renal disease
Nature neuroscience 2019;22, 719728, doi: Bhat, R
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