what's the difference between retatrutide and tirzepatide vs. Tirzepatide: Difference? – Forbes Health Semaglutide vs Tirzepatide vs Retatrutide

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Medication Mechanism of Action Average Weight Loss Retatrutide Triple agonist (GLP-1, GIP, Glucagon) Up to 24% average weight loss over 48 weeks Semaglutide GLP-1 receptor agonist Up to 17% over 68 weeks Tirzepatide Dual agonist (GLP-1, GIP) Up to 25% over 52 weeks Retatrutide is used to help with weight loss

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Note: These trials differ in design, duration, and populations, so comparisons are approximatenot head-to-head