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Melanotan II acts as a non-selective agonist with nanomolar-range affinity at MC1R, MC3R, MC4R, and MC5R, with relative potencies varying by assay system but generally showing highest functional activity at MC1R and MC4R in cAMP accumulation assays using transfected cell lines
A standard cycle runs 12 weeks on followed by 4 weeks off
Supplementing with a bioavailable form is often necessary to significantly raise systemic levels
It may aggregate into clumps that the body cannot use
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