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After eight weeks, leg heaviness was reported to be reduced by 60.4% in the Pycnogenol group compared to a reduction of 12.6% in the placebo group

These central pathways should therefore be regarded as biologically plausible but pharmacologically speculative in the clinical context, pending direct evidence of sufficient CNS target engagement

In a study of blood samples from 58 Parkinsons disease patients, they found that glutathione levels not only declined with age, they were also correlated with statistically significant improvements in scores on the Unified PD Rating Scale (UPDRS), which is commonly used to measure Parkinsons disease severity based on patients symptoms, as well as the Patient-Reported Outcomes in PD, another symptom-based scale

The ratio of GSH to GSSG is one of the most sensitive indicators of cellular health