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Sikiric P., Seiwerth S., Grabarevic Z., Rucman R., Petek M., Jagic V., Turkovic B., Rotkvic I., Mise S., Zoricic I., Perovic D., Simicevic V., Hanzevacki M., Ljubanovic D., Artukovic M., Bratulic M., Tisljar M., Rekic B., Gjurasin M., Miklic P., Buljat G., Pentadecapeptide BPC 157 positively affects both non-steroidal anti-inflammatory agents-induced gastrointesti- nal lesions and adjuvant arthritis in rats, J

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This copper-binding motif is critical: the apo-peptide (GHK without copper) shows substantially reduced biological activity in most in vitro assays, indicating that the metal center is required for receptor interaction and downstream signaling