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In published preclinical research, GHK-Cu has been examined across in vitro fibroblast and keratinocyte cultures (PMID 19319546, PMID 23019153), murine wound-healing and tissue-remodelling models (PMID 38879894, PMID 39902373), and broader gene-expression-profiling work in cell culture (PMID 28212278, PMID 29986520)

This aligns with findings from similar studies on other GLP-1 receptor agonists like semaglutide and liraglutide, which carry same boxed warning and have also not shown increased thyroid cancer rates in human populations

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