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If you experience persistent or worsening mental health symptoms, including suicidal thoughts, call or text 988 to reach the Suicide and Crisis Lifeline for immediate support

A 2024 phase 2 RCT documented 2.6% hip and 2.1% lumbar spine bone density reductions within 52 weeks at the 1.0 mg semaglutide dose in a specific study population

The regain is not inevitableresearch demonstrates that people who establish sustainable eating patterns, maintain regular physical activity, and address underlying metabolic factors often keep 30-50% of their initial weight loss even after stopping the medication

While regulated markets could see a sharp near-term upside, the opportunity there may moderate over time due to pricing pressure and competition, the report noted