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In addition, L-theanine (100 mg/kg) could effectively regulate the metabolism of glucose, lipids, and proteins in SD rats, and the main mechanism was that L-theanine could upregulate the mRNA expression of phosphofructokinase (PFK), carnitine palmitoyltransferase 1 (CPT1), insulin receptor (IR), insulin receptor substrate (IRS), and liver kinase B1 (LKB1), and enhance the phosphorylation of adenosine 5-monophosphate-activated protein kinase (AMPK) (79)
Hum Mol Genet 32:10901101
These findings collectively emphasize that while GLP-1RAs are effective in reducing FBM, strategies to preserve or enhance SMM, such as resistance training and adequate protein intake, should be integral to obesity management
That means a real evaluation up front, a dose set by a prescriber, and someone accountable if a side effect shows up the safeguards that keep glutathione on the well-tolerated end of the spectrum
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