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Patients beginning treatment with semaglutide can expect a gradual weight loss trajectory

These novel treatments aim to not only help patients shed excess weight but also improve metabolic health, reducing the risk of obesity-related conditions like diabetes and cardiovascular disease

Both TNF- and IL-6 can reduce the expression of intracellular glucose transporter 4 (GLUT4), inhibit normal phosphorylation of insulin receptors and insulin receptor substrate 1 (IRS-1), block GLUT4 translocation, and lead to IR

Of the employers that said their health plan offerings do not cover GLP-1s for weight loss, a majority said they were not likely to begin covering GLP-1s for weight loss within the next 12 months (and only 1% said they were very likely to do so)