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For example, Jessen et al 132 demonstrated that central administration of GLP-1 increased neuronal activity in brain regions (PVN and NTS), thereby mediating autonomic nervous system, as well as activation of HPA axis and stimulation of circulating levels of corticosterone and epinephrine
doi:10.1016/j.biopha.2020.110137
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It often worsens over time, leading to permanent damage
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