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An imbalance of the gut microbiota can lead to immune activation and inflammation, particularly through an increase in pro-inflammatory lipopolysaccharides (LPS), which results in increased production of inflammatory cytokines, such as TNF-, IL-1, and IL-6 (218)

This reaction not only converts toxic oxidants into harmless substances (such as water) but also creates conditions for the subsequent reduction process by storing electrons in disulfide bonds

This work established the broader significance of NNMT in methylation-dependent cellular processes and provided context for the development of selective inhibitors [3]

doi: 10.1136/ard.2010.143040 Summary Keywords rheumatoid arthritis, targets, proteins, small molecular metabolites, epigenetic regulators Citation Huang J, Fu X, Chen X, Li Z, Huang Y and Liang C (2021) Promising Therapeutic Targets for Treatment of Rheumatoid Arthritis