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As a vital constituent of antigen-presenting cells (APCs), macrophage possesses two exact opposite-in-function phenotypes, M1 and M2, the former polarized by lipopolysaccharide (LPS), producing pro-inflammatory cytokines such as IL-1, IL-6, IL-12, IL-23, and TNF-, the latter polarized by Th2 cytokines, producing anti-inflammatory cytokines such as IL-10 and TGF- [20]
WEIGHT MANAGEMENT PROGRAMMES TAKE TIME AND PERSONAL COMMITMENT TO BE EFFECTIVE, AND ALSO REQUIRE DIET, EXERCISE AND LIFESTYLE CHANGES
10.1007/s12017-013-8280-8 56 LiuQ.ChengL.MatsuuraA.XiangL.QiJ
Skin tone, clarity, and overall radiance improve gradually with regular use
