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BPC-157 is still in experimental stages in veterinary medicine, and is not recognized as a standard approved treatment to dogs

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Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)

Helps to bring calcium levels back to normal in hypocalcemic dogs, which helps to minimize complications due to the calcium deficiency