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In rodents there is high expression of GLP-1Rs in the calcitonin-producing C-cells of the thyroid, and activation of these receptors by GLP-1RAs stimulates the adenylate cyclase pathway, leading to upregulation of calcitonin synthesis and, subsequently, hyperplasia and an increased incidence of adenomas (88)
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More serious concerns include a possible increased risk of pancreatitis (inflammation of the pancreas) and, in animal studies, thyroid C-cell tumors
Szacuje si, e w populacji polskiej z nadwag zmaga si a 44% wszystkich mczyzn i 30% kobiet , a liczba ta stale ronie i obejmuje coraz to modsze roczniki
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