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Grade drives the choice: mild and moderate dysplasia usually stay at D22.4, while D48.5 applies only when the pathologist documents severe dysplasia or uncertain behavior
The evidence suggests that hypogonadism in CKD correlates with worse outcomes: more cardiovascular complications, greater muscle wasting, more severe anemia, poorer survival on dialysis
Understanding these factors helps researchers correctly interpret divergent pharmacokinetic observations and adjust experimental designs accordingly
The main issue with B12 shots or B12 injections is that they can be somewhat difficult to obtain
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