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After 104 weeks of treatment, the primary outcome of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke occurred in 6.6% of the patients in the semaglutide group and 8.9% of those in the placebo group, resulting in a hazard ratio (HR) of 0.74 (95% CI 0.580.95) [13]

Many people regain 50% or more of lost weight within 12 months after stopping, which is why ongoing therapy or robust lifestyle changes are critical for long-term success

Even modest improvements in quadriceps strength have been shown to reduce knee pain by up to 30% in patients with knee osteoarthritis