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Given the clear relationship between IGF-1 and aging, we reasoned that IGF-1R mAbs could provide a translational tool to mimic the beneficial effects reported by reduced signaling in this pathway

The emerging realization that the gut microbiota and its associated metabolites regulate intestinal barrier functions 10,11,12 drove us to investigate whether the advantages of the gut organ culture system could be harnessed to uncover mechanisms underlying microbial regulation of gut permeability

J Biol Chem 287(7):45524561 DAutraux B, Toledano MB (2007) ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis