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1965 Oct;6(5):472-6
This isnt about willpower
Niacinamide (vitamin B3, technically not peptide but frequently combined in peptide formulations ) addresses pigmented dark circles through multiple mechanisms including inhibiting melanosome transfer from melanocytes to keratinocytes reducing visible pigmentation, anti-inflammatory effects decreasing post-inflammatory hyperpigmentation from rubbing or allergies, and barrier strengthening improving overall skin health and resilience
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If the kidneys are already under strain (which is common with age, diabetes, or high blood pressure), this direct load can be too much to handle
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