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Water: How Much Should You Drink Every day
Mechanisms by which the barrier is disrupted include direct changes to the integrity of the bloodbrain barrier via impaired tight junctions and adhesion proteins, leading to increased permeability [246, 247] and changes in barrier cell concentration and increased localized secretion of inflammatory proteins [248, 249]
Acknowledgements The authors would like to thank the Stanford University Veterinary Service Center for their assistance and care of animals used in this study, and Ben Franco and Kaleigh Beacham for their support with collection of blood
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