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Palmitate, partly a product of hepatic de novo lipogenesis, has a particularly detrimental role in reducing -cell function, most likely by inducing -cell dedifferentiation 50

By modulating key regulatory systems, Retatrutide has demonstrated the ability to elicit positive changes in various aspects of health, from metabolic function to cardiovascular resilience

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First, an insulin-secreting -cell line MIN-6 cells stably expressing GLP-1R (GLP-1R-MIN-6 cells) was prepared, as we intended to observe a stronger effect of GLP-1R activation than that of endogenous GLP-1R