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Senescent cells accumulate over time and are characterized by altered gene expression, resistance to apoptosis, and secretion of inflammatory mediators collectively referred to as the senescence-associated secretory phenotype (SASP)
And while the redness and induration can look alarming, they typically resolve within 24 to 72 hours without intervention
The initial colonization of CRC tissues is facilitated by extracellular vesicles derived from F.n (FnEVs), which transfer the outer membrane protein FomA to cancer cells, creating a niche for bacterial adhesion and aggregation (Zheng et al., 2024)
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