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Diphenyleneiodonium (DPI), a flavoenzyme inhibitor, not only prevented the formation of the NFT radical anion in microsomal preparations (Fig
Although pentavalent methylated arsenicals (MAs V , DMAs V , TMAs V ) are less toxic than inorganic ones (iAs V , iAs III ), the trivalent intermediated formed during the methylation process (MAs III , DMAs III ) are much more cytotoxic and genotoxic (Hughes, 2009)
Liquid chromatography-tandem mass spectrometry (LC-MS/MS), which is particularly stable in plasma samples stored at 80C for up to 5 years, can be used to precisely analyze TMAO [5, 85, 86]
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