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We monitored levels of antibodies against LCMV Cl13 glycoprotein 1 (Gp1) by ELISA at various time points after infection and observed that both early (IgM) and late (IgG) responses were undetectable in serum of infected mutant mice, in contrast to infected controls (Fig
Transcriptomic analysis revealed profound downregulation of mitochondrial functions, including oxidative phosphorylation, the TCA cycle, and fatty acid -oxidation, alongside disruption of the sirtuin pathway and extracellular matrix remodeling
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