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The ratio between the two dominant phyla Firmicutes/Bacteroidetes (F/B) is often defined as a potential biomarker for a variety of disorders

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( Reference Martinov, Vitvitsky and Mosharov 39 ) , in a mathematical modelling study of SAM metabolism in the liver, stated that when SAM levels are low, priority for this substrate goes to transmethylation reactions, promoting reduction of the trans-sulfuration pathway

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