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Since its isolation and characterisation in the early 1990s, it has become one of the most extensively studied peptides in regenerative biology research, with a broad research profile spanning gastrointestinal, musculoskeletal, vascular, and neurological tissue models
The latest research pointed out that irisin is derived from its precursor protein fibronectin type III domain-containing protein 5 (FNDC5), which can be released from various tissues such as skeletal muscle, fat, and pancreas, mainly involved in the transformation of WAT to BAT, thereby increasing the bodys energy expenditure
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