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Decreasing the dosage often diminishes or eliminates drug-related patient body odor or gastrointestinal symptoms when present

It is particularly notable for its receptor selectivity, pharmacodynamic profile, and preclinical effects on endocrine systems, distinguishing it from earlier growth hormonereleasing peptides (GHRPs)

As in the previous recommendations by the ADA and EASD (73, 74), life-style intervention (with patient education and motivation, increase of physical activity, and healthy eating) is still in the beginning and center of therapy, followed by pharmacological therapy with metformin (7074)

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