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Synthesis and characterization of GLP-1RAs@NPs-WYRGRL To enhance the local concentration, stability, and retention time of GLP-1RAs in the joint area, GLP-1RAs were encapsulated into silk fibroin nanoparticles (GLP-1RAs@NPs) and the surface of GLP-1RAs@NPs was further modified with the WYRGRL peptide, thereby developing GLP-1RAs@NPs-WYRGRL for the treatment of RA (Fig

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However, injections are typically used for whole-body peptide protocols, while GHK-Cu topicals provide targeted application for cosmetic enhancement

These adverse effects remain the most common reason for discontinuation of GLP-1 RAs therapy (46)